Josh Mitteldorf

1. https://old.reddit.com/r/longevity/ 2. https://joshmitteldorf.scienceblog.com (be sure to follow the links to research papers and read the comments) 3. I also made a playlist with videos and lectures on the topic: https://www.youtube.com/playlist?list=PLLvA7pB41pDk27XOjqbXi4sSvPfLOu1…

Josh Mitteldorf's blog is good for life extension updates: https://joshmitteldorf.scienceblog.com/

> As a minor question, we see these studies a lot in mice. Are they being followed up in other animals and humans? Yeah, lots of aging studies exist. https://joshmitteldorf.scienceblog.com/2017/02/06/glycine-and-mitochon… https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002905/ "Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults Glycine and N‐acetylcysteine (GlyNAC) supplementation in older adults" I have many examples of the above, in the UK the NHS stance is to give everyone and anyone who is elderly in a care home a b12 shot when possible, which is just a form of cobalt, but that assumes they have enough cysteine!

48-72 hours is not long enough to regenerate your immune system. Valter Longo has recommended at least 4-5 days to treat auto-immune disorders [1]. I've done 5 day fasts. For something serious I would try 7. [1] http://joshmitteldorf.scienceblog.com/2014/06/12/the-three-day-fast-da… “3 days is optimal for mice. For humans 4-5 minimum, depending on what you are trying to achieve”

From the paper (DEEX - "Depressed mood and exhaustion"): "Nonetheless, adding DEEX to a risk score based on classical risk factors resulted in only nonsignificant improvement of mortality risk prediction." Regarding the causal relationship: "Although not a proof of causality, in general, depressed subjects are more likely to cluster self-harming lifestyle behaviors and may be less likely to adhere to prescribed medication." To put things in context it is also worth noting that, except in old age, a big increase in the risk of death at any given point of time translates into a very small reduction in life expectancy. See for example http://joshmitteldorf.scienceblog.com/2012/11/10/mortality-and-life-ex…

OP here. I have read Josh Mitteldorf blog[1] in the past, but was completely unaware of his line of reasoning regarding aging. This sentence[2] caught my attention: Genes are turned on that destroy us with inflammation and cell senescence and auto-immunity and programmed cell death, while the systems that protect us from pathogens and from free radical damage are gradually shut down. Evolution has left nothing to chance. And then, the reference to the "Gilgamesh project" seems appropriate: As of now, the GILGA-Mesh project is dominated by numbers geeks (like me) who practice the “Google approach” to bioinformatics. Huge databases of gene expression are screened for epigenetic candidates that seem to be well-correlated with good outcomes. I think what we need is an infusion of biolochemists who understand something about the body’s signaling networks, and can orient us toward “upstream” and “downstream” molecules [2] So, I am just posting this in the hope that some biolochemist wants to join this project. [1] http://joshmitteldorf.scienceblog.com/ [2] http://joshmitteldorf.scienceblog.com/2016/05/09/epigenetics-of-aging-…

If you read the article, the claim was made further up with a link to posts why the author believes it. Quote: > This spike protein was engineered in a bioweapons lab[1] to be toxic in multiple ways Claims seems surprisingly coherent and detailed, though I have serious doubts WRT author's selective perception bias. [1] https://joshmitteldorf.scienceblog.com/2020/04/21/where-did-covid-19-c…

Google, when used with double quotes and exact title, finds aggregator sites, but I was simulating looking for the original: https://joshmitteldorf.scienceblog.com/2020/07/08/politics-influences-… Here is one more, search: Ten Elements of the False COVID Narrative Google: nowhere Brave: first result And it's not like Google just didn't index the site, it works for topics that are "less controversial", search: Universal Clock implies Universal Clockwork Google: first result Brave: first result Whatever the explanation - either Google censors some topics, or its search engine works differently - the result is the same, for this example Brave outperformed Google.

>And glad the research suggests it. The article is actually arguing against aging being inevitable (in the article, "My answer may be right or wrong" and below). The author also links to a blog titled "Age reduction breakthrough"~[1]. [1] https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakt…

Thanks for pointing out that! Here is the article about the COVID-19 and Bill Gates on the same page: https://joshmitteldorf.scienceblog.com/2021/05/10/unthinkable-thoughts…

Probably the intended submission was https://joshmitteldorf.scienceblog.com/2021/06/17/is-aging-inevitable/

Blog post which comments on the paper https://joshmitteldorf.scienceblog.com/2021/06/17/is-aging-inevitable/

This effect is called hormesis [1] and is quite established for various kinds of stressors. For example also in the context of oxygen depriving breathing exercises and cold baths [2] (which is how I came across the term only this week). On the topic of bloodletting and blood donations, I found these interesting considerations [3]. There is a correlation of less cardiovascular disease among people who donate blood. Of course there are lots of confounding factors here. The article summarizes them nicely. [1] https://en.wikipedia.org/wiki/Hormesis [2] https://news.ycombinator.com/item?id=24676116 [3] https://joshmitteldorf.scienceblog.com/2015/11/09/does-donating-blood-…

A blog post about existing information about plasma exchange in humans: https://joshmitteldorf.scienceblog.com/2020/06/29/human-trials-of-plas…

Overview: https://joshmitteldorf.scienceblog.com/2020/05/11/age-reduction-breakt…

It could be, though with a bit of Googling I found this blog post summarizing scientific studies that suggest otherwise. https://joshmitteldorf.scienceblog.com/2016/05/16/no-animal-dies-of-ol…

Josh Mitteldorf's nascent project using the Horvath Clock might be of interest to some people here. https://joshmitteldorf.scienceblog.com/2018/04/08/the-mother-of-all-cl…

This is a copy without attribution of a post that Josh Mitteldorf made a few days ago: https://joshmitteldorf.scienceblog.com/2017/12/31/the-other-half-of-sc…

From another of the author's articles: In limited studies with mice, telomerase enhancers have led to rejuvenation. http://joshmitteldorf.scienceblog.com/telomerase-as-a-fountain-of-yout…

Okay, fair enough. But a major difference is that flu deaths are much more heavily burdened on the the young, whereas Covid is on the very elderly. The death of a 6 month old from flu results in approximately 20 times more QALY loss than an 85 year old. Let me approach it from another angle. Pre-vaccine, it appears that Covid roughly doubled everyone's all-cause mortality.[1] Like it killed 30 year olds at a much lower rate than 90 year olds, but 30 year olds have a much lower baseline mortality to begin with. This isn't an exact relationship, but approximately about double mortality across the board. (Even interestingly enough men's excess Covid death rate is about in line with their general mortality vis-a-vis women.) The vaccine appears to reduce the mortality risk of circulating Covid by about a factor of 100X. There's very little reason to believe that it substantially shifts the relative mortality burden between groups. So, post-vaccine Covid increases all-cause mortality broadly by about 1%. That translates into less than 1 month of lost life expectancy.[2] [1]https://pubmed.ncbi.nlm.nih.gov/33412438/ [2]https://joshmitteldorf.scienceblog.com/2012/11/10/mortality-and-life-e…