Fight Aging!

OT: just wanted to say Fight Aging [1] is an amazing, inspiring model for how modern public interest initiatives should work IMO. Thank you. [1] https://www.fightaging.org

> Have you also checked the source? It's not a scientific publication That's probably something to do with Wikipedia's editing guidelines these days. They have a rule against using primary research citations. Only literature reviews, books, and other secondary sources are acceptable. I found the original source for the claim, which may be no better for supporting the claim for a number of reasons (why has this not been replicated, or did replication fail?): http://www.sciencedirect.com/science/article/pii/0531556573900247 Effect of dimethylaminoethyl p-chlorophenoxyacetate on the lifespan of male Swiss Webster albino mice, J Exp Gerontol 8: 177, 1973 Author: R. Hochschild of "Microware Instruments Co" of California. doi (for sci-hub): 10.1016/0531-5565(73)90024-7 http://www.sciencedirect.com/science/article/pii/0531556573900247 Note: If anyone is actually interested in the field of biogerontology, I recommend following the https://www.fightaging.org blog for editorialisation of news and research papers coming out of the field.

There is Reason who runs a successful biotech company, and his corpus of writing at https://fightaging.org His commentary on new papers in ageing is pretty good, in my opinion. He has a good coverage of NIA ITP trials as well: https://duckduckgo.com/?q=site%3Afightaging.org+NIA&ia=web

Some of the more noteworthy lessons I have learned to date as a result of running a longevity industry biotech startup, most of which likely apply to any biotech initiative, were incorporated into the "Notes on Starting a Biotech Company" section of this document: https://www.fightaging.org/pdf/how-to-start-a-biotech-company-in-the-l…

Fight Aging! is a long running blog on longevity science (now more than 10 years old) and their take is usually worth reading. Here is their take on Elysium Health: https://www.fightaging.org/archives/2016/07/an-educational-article-on-…

In the short term, get the highest-paying software engineering job you can, and donate a meaningful part of your income to charitable organizations working on anti-aging research such as SENS. (Check if your employer matches charitable donations, as well.) Much more efficient and effective than rethinking your entire career just so you can add one person's worth of time to such an effort. (That's not to say "don't work on the problem directly", and there are jobs in that effort for software engineers, but don't feel like you can't contribute unless you can directly work on the problem.) I'm currently sponsoring a matching fund for new recurring supporters of SENS, starting in November: every new recurring donation gets matched for a year, up to $24k. See https://www.fightaging.org/fund-research/

He is the mastermind behind https://www.fightaging.org/ and Longecity guardian[2] [2] http://www.longecity.org/forum/user/137-reason/

This is just an ad masquerading as research, I'm flagging this. I mean, please: "Calvin Harley is one of the inventors of TA-65. He consults for TA Sciences and is personally taking TA-65. He owns stock and stock options in Geron Corporation, a company that is developing telomerase activators for therapeutic purposes and the company that licensed TA-65 to TA Sciences." how transparent can you be. Also, if something is present in nature you discover it, you don't invent it. If you google around a bit, elsewhere they claim it can cure cancer and will cause wounds to heal rapidly. Amazing compound, really. Interesting comments here: http://www.fightaging.org/archives/2007/04/more-on-ta-sciences-ta65.ph… On http://www.quackwatch.com/ the publisher Marie Ann Liebert, Inc is listed as a publisher that promotes quakery.

If you must read a book, Ending Aging by Aubrey de Grey is maybe the best introduction but IMO you're still better off reading the papers/tracking the latest research if you're interested in the topic. You'll save a lot of time and be more up to date, as it's a rapidly developing field: West, Michael D, Hal Sternberg, Ivan Labat, Jeffrey Janus, Karen B Chapman, Nafees N Malik, Aubrey DNJ de Grey, and Dana Larocca. “Toward a Unified Theory of Aging and Regeneration.” Regenerative Medicine 14, no. 9 (August 28, 2019): 867–86. https://doi.org/10.2217/rme-2019-0062. Shetty, Ashok K., Maheedhar Kodali, Raghavendra Upadhya, and Leelavathi N. Madhu. “Emerging Anti-Aging Strategies - Scientific Basis and Efficacy.” Aging and Disease 9, no. 6 (December 4, 2018): 1165–84. https://doi.org/10.14336/AD.2018.1026. Brown-Borg, Holly M., and Rozalyn M. Anderson. “Metabolic Adventures in Aging Research.” Molecular and Cellular Endocrinology, Metabolism of Aging, 455 (November 5, 2017): 1–3. https://doi.org/10.1016/j.mce.2017.08.012. Longo, Valter D, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, et al. “Interventions to Slow Aging in Humans: Are We Ready?” Aging Cell 14, no. 4 (August 2015): 497–510. https://doi.org/10.1111/acel.12338. López-Otín, Carlos, Maria A. Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer. “The Hallmarks of Aging.” Cell 153, no. 6 (June 6, 2013): 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039. A…

Actuarial escape velocity is a term popularized by Aubrey de Grey, first put forward a while back and then in a 2004 PLoS Biology paper [1] following some of the bioethics debates of the past decade. Most of you will probably recall those debates in the context of somatic cell nuclear transfer, embryonic stem cells, and therapeutic cloning, but the various appointed bodies pontificated on aging and longevity science as well. Generally to say how terrible it was to even think about extending healthy human life, but hey, what can you expect? That is more or less the default position that most people still hold today [2]. To a certain degree one has to come to terms with the fact that most people in the world hold incoherent views on the topic of aging to death. If asked most of them say they want to: they want to do exactly the same thing they see other people doing. Conformity is a hell of a drug. But if asked if they want to suffer heart disease or Alzheimer's, they don't want that. Then there is the hairshirt environmentalist death cult that tells us we're destroying the world, there are too many people, and we should all die. That is not actually much of an exaggeration of the actual viewpoints espoused. This has so pervaded society that you can find the average person on the street is concerned about living too long because they are someone burning up a limit faster. It's ridiculous. People look at the horrible consequences of war and kleptocracy in various regions [3],…

https://rapamycinstudy.org/ is collecting data on off-label use according to https://www.fightaging.org/archives/2022/04/collecting-data-on-people-… (reasonatllm who runs that site hasn't commented on this site recently, perhaps they are busy running https://www.repairbiotechnologies.com/)

Interesting that there is no mention of hydrogen peroxide. About 10 years ago, there was a flurry of news that greying hair was a result of a buildup of hydrogen peroxide[1]. Many scientists guessed that this buildup was caused in part by lack of sleep, as they believed that one of the benefits/purposes of sleep was the removal of hydrogen peroxide, and other waste, from cells. The lead photos in many of these articles was side by side photos of presidents at their inaugurations and at some point during their term. [1] See, e.g. https://www.fightaging.org/archives/2013/05/reversing-hair-grayness-by…

More on Underdog Pharma: https://www.fightaging.org/archives/2019/11/an-interview-with-matthew-… "We've taken a well-known and extremely safe compound, and have created novel derivatives that can specifically target the toxic biomolecule that drives the development of atherosclerosis, the cause of most heart attacks and strokes." I'm excited for this one. Seems like a reasonable possibility for success addressing a huge killer.

That was their old post copypasted: https://www.fightaging.org/archives/2009/12/the-maesgarreau-tendency.p… You can ask there, or search through that blog.

Thanks for sharing the link (*edit: and writing it, I just realized). Another interesting comment from it: When it comes to what is shouted from the loudspeakers on a given day, it's all a matter of accident and marketing rather than facts and understanding. For example, you might recall that telomerase and p53 were used to extend normal mouse life span by 50% a few years ago[1] - far more important and interesting than this present study, yet it received next to no attention. [1] http://www.fightaging.org/archives/2008/01/50-maximum-life-extension-i…

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I have a strong belief that there definitely are lifestyle changes you can make in order to lower your chances of getting Alzheimer's, and there is some support for them, although they need more research in order to confirm the exact magnitude and effect. Some of the ones which I believe are worth taking a closer look at are listed below: – Regular exercise may delay Alzheimer's in those at high risk of disease: https://inews.co.uk/news/health/regular-exercise-delays-alzheimers-hig… – Dr. Dale Bredesen Protocol: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4712873/ – Control Hypertension: https://www.fightaging.org/archives/2020/01/controlling-hypertension-r… – DASH diet: Healthy eating to lower your blood pressure: https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eat… – Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671587/ – Alzheimer's Disease Is Type 3 Diabetes–Evidence Reviewed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769828/ Some good reading and support for the herpes / viral hypothesis is provided below: – Alzheimer's risk 10 times lower with herpes medication: https://www.medicalnewstoday.com/articles/322463 – Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection:…

This has been addressed many times (and btw, people wouldn't live "forever" -- you can still be hit by a truck, at least until we can backup brains). http://fightaging.org/archives/2006/09/overpopulation.php But in general, you have to ask if the problem that would be solved is bigger than this new potential problem, and do we have the right to make the decision not to develop these therapies and condemn future generation to die from aging? Every day that they are delayed, thousands die. Maybe hard choices will have to be made: very low birth rates, or some rate of voluntary deaths (religious people who refuse to take the therapies, maybe?), etc. Maybe it'll be no problem because of technological advances (molecular manufacturing, advanced biotech, etc) and we'll have more than enough resources for everybody, and can colonize other planets. But these problems caused by people not dying so much seem to be smaller than 100k-150k people dying each day after a long-period of suffering and frailty, causing pain to their families and friends. We've cured many diseases and fixed many of humanity's problems so far, and the benefits seem to outweigh the costs. Goal #1 is to cure diseases, living longer is just a side-effect, as it always was. Objections to curing the diseases of aging must be at least as big as the problem. Otherwise it's the same old thing about overpopulation that has been going around ever since we invented sanitation and vaccines.